Genetics of cancer

We use a variety of techniques to interrogate three basic themes in the biology and clinical behavior of these deadly cancers:

(1) Intra-patient tumor heterogeneity at the temporal and anatomic levels,

(2) Inter-patient heterogeneity between different patients, and

(3) Tumor-microenvironmental interactions.

We use a combination of genetically engineered mouse models, cell lines, and clinically derived samples to interrogate multiple genomic outputs with a focus on genomic DNA and mRNA.